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GLP-1 users who have lost 40 pounds or more, particularly those who lost weight rapidly over several months Patients with pre-existing conditions that thin fat pads including those with diabetes, which is itself associated with reduced plantar fat pad volume who then experience additional fat loss from GLP-1 medications People who are on their feet for extended periods including nurses, teachers, retail workers, restaurant staff, and anyone with a standing-dominant occupation who may experience pain earlier due to higher mechanical demand Patients who have not updated their footwear since beginning GLP-1 medication and may now be wearing shoes that no longer fit correctly Symptoms and Warning Signs to Watch For GLP-1 users who experience the following should make an appointment with a podiatrist: New foot pain, particularly in the heel or ball of the foot, that was not present before beginning the medication A sensation of walking on pebbles or stones in shoes that previously felt comfortable Visible changes to the top of the foot prominently visible veins, tendons, or bones where padding previously obscured them Skin on the feet that looks or feels loose, wrinkled, or deflated Shoes that no longer fit correctly, particularly in width These symptoms do not require emergency care

2D cultures Pre-differentiated HepaRG cells or LSECs were seeded on collagen A-coated 96-well plates

Positive mindset correlates with better healing outcomes independent of interventions